Louis A.
Gatto, Professor and Department ChairLouis A.
Gatto, Professor and Department Chair| Room: | |
| Phone: | 607-753-2716 |
| E-mail: | gatto@cortland.edu |
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ADDITIONAL ADJUNCT APPOINTMENT: |
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Research Professor |
Fordham University, M.S., Ph.D.
Doctoral work focused on mucociliary transport in the trachea (supported by Grant HL-16730 from the National Heart, Lung, and Blood Institute of N.I.H). Mucus clearance rates were measured in vitro and a novel methodology was developed for the measurement of viscosity, elasticity and adhesiveness of mucous secretions. The objective of this work was to define mechanisms involved in the autonomic modulation of mucociliary clearance.
Subsequent research activities at SUNY/Cortland are shared with co-authoring students and involve the study of histochemical changes in tracheal glands and in the pH of tracheal mucus following pharmacological stimulation in several animal models.
Current research is carried out in liaison with the Surgery Department at SUNY Upstate Medical University College of Medicine at Syracuse, and involves the development of an animal model for the study of Adult Respiratory Distress Syndrome (ARDS). The work at Syracuse entails the surgical instrumentation of a porcine sepsis model, while the subsequent histometric evaluation of lung tissues is done at Cortland. The research team includes Cardiopulmonary Surgeons, Surgery Residents and Research Scientists from the College of Medicine, and the work closely parallels ARDS as it occurs in patients at the Intensive Care Unit at University Hospital.
We recently developed and patented an approach for treatment. Gatto is Co-Inventor in U.S. Patent No. 5,977,091 on "Method of Preventing Acute Lung Injury." Assignee: The Research Foundation of SUNY. U.S. Class: 514/152. International Class A61K031/65. [http://www.uspto.gov/patft/index.html]
Year 2006
DiRocco JD, Pavone LA, Carney DE, Lutz CJ, Gatto LA, Landas SK, Nieman GF. "Dynamic alveolar mechanics in four models of lung injury." Intensive Care Med, 32(1): 140-148, 2006.
Halter JM, Pavone LA, Steinberg JM, Gatto LA, DiRocco J, Landas S, Nieman GF. "Chemically-modified tetracycline (COL-3) improves survival if given 12 but not 24 hours after cecal ligation and puncture." Accepted for Publication in Shock
McCann UG, Lutz CJ, Picone AL, Searles B, Gatto LA, Dilip KA, Nieman GF. "Whole blood cardioplegia (minicardioplegia) reduces myocardial edema after ischemic injury and cardiopulmonary bypass" J Extra Corpor Technol, 38:14-21, 2006.
Swartz MF, Halter JM, Fink GW, Pavone L, Zaitsev A, Lee HM, Steinberg JM, Lutz CJ, Sorsa T, Gatto LA, Landas S, Hare C, Nieman GF. "Chemically modified tetracycline improves contractility in porcine coronary ischemia/reperfusion injury." J Card Surg 21(3): 254-260, 2006.
Year 2005
Makarenko IG, Meguid MM, Gatto L, Chen C, Ramos EJ, Goncalves CG, Ugrumov MV. "Normalization of hypothalamic serotonin (5-HT 1B) receptor and NPY in cancer anorexia after tumor resection: an immunocytochemical study." Neurosci Lett, 383(3): 322-327, 2005.
Makarenko IG, Meguid MM, Gatto L, Goncalves CG, Ramos EJB, Chen C, Ugrumov MV. "Hypothalamic 5-HT1B-receptor changes in anorectic tumor bearing rats." Neurosci Lett, 376(2): 71-75, 2005.
Steinberg J, Halter J, Schiller H, Gatto L, Carney D, Lee H-M, Golub L, Nieman G. "Chemically modified tetracycline prevents the development of septic shock and acute respiratory distress syndrome in a clinically applicable porcine model." Shock, 24(4): 348-356, 2005.
Steinberg J, Halter J, Schiller H, Gatto L, Nieman G. "The development of acute respiratory distress syndrome model after gut ischemia/reperfusion injury followed by fecal peritonitis in pigs: A clinically relevant model." Shock, 23(2): 129-137, 2005.
Steinberg JM, Schiller HJ, Tsvaygenbaum B, Mahoney GK, DiRocco JD, Gatto LA, Nieman GF. "Wood smoke inhalation causes alveolar instability in a dose dependent fashion." Respir Care, 50(8): 1062-1070, 2005.
Year 2004
Gatto LA, Fluck R., Nieman GF. "Alveolar mechanics in the acutely injured lung: Role of alveolar instability in the pathogenesis of ventilator-induced lung injury." Respir Care, 49 (9): 1045-1055, 2004.
Steinberg JM, Schiller HJ, Halter JM, Gatto LA, Lee H-M, Pavone LA, Nieman GF. "Alveolar instability causes early ventilator-induced lung injury independent of neutrophils." Am J Respir Crit Care Med, 169(1): 57-63, 2004.Year 2003
Halter JM, Steinberg JM, Schiller HJ, DaSilva M, Gatto LA, Landas S, Nieman GF. "Positive end-expiratory pressure after a recruitment maneuver prevents both alveolar collapse and recruitment/derecruitment." Am J Respir Crit Care Med, 167:1620-1626, 2003.
Makarenko IG, Meguid MM, Gatto L, Chen C, Ugrumov MV. "Decreased NPY innervation of the hypothalamic nuclei in rats with cancer anorexia." Brain Res, 961:100-108, 2003.
Schiller HJ, Steinberg J, Halter J, McCann U, DaSilva M, Gatto LA, Carney D., Nieman G. "Alveolar inflation during generation of a quasi-static pressure/volume curve in the acutely injured lung." Crit Care Med, 31(4):1126-1133, 2003.
Steinberg J, Halter J, Schiller HJ, DaSilva M, Landas S, Gatto LA, Maisi P, Sorsa T, Rajamaki M, Lee H-M, Nieman GF. "Metalloproteinase inhibition reduces lung injury and improves survival after cecal ligation and puncture in rats." J Surg Res, 111:185-195, 2003.
Year 2002
Darling E, Searles B, Nasrallah F, Robins M, You X, Gatto L, Clay N, Picone A, Steinberg J, Nieman G. "High-volume balanced ultrafiltration improves pulmonary function in a model of post-pump syndrome." J Am Extra-Corp Tech, 34:254-259, 2002.
McCann UG, Schiller HJ, Gatto LA, Steinberg JM, Carney DE, Nieman GF. "Alveolar mechanics alter hypoxic pulmonary vasoconstriction." Crit Care Med, 30(6)1315-1321, 2002.
Steinberg J, Schiller HJ, Halter JM, Gatto LA, Dasilva M, Amato M, McCann UG, Nieman GF. "Tidal volume increases do not affect alveolar mechanics in normal lung but cause alveolar overdistension and exacerbate alveolar instability after surfactant deactivation." Crit Care Med, 30 (12):2675-2683, 2002.
Year 2001
Carney D.E., McCann U.G., Schiller H.J., Gatto L. A., Steinberg J., Picone A.L., Nieman G.F. 2001. "Metalloproteinase inhibition prevents acute respiratory distress syndrome." J. Surg. Res., 99:245-252
McCann II U.G., Schiller H.J., Carney D.E., Gatto L. A., Steinberg J.M., Nieman G.F. 2001. "Visual validation of the mechanical stabilizing effects of positive end-expiratory pressure at the alveolar level." J. Surg. Res., 99:335-342
McCann UG, Schiller HJ, Carney DE, Kilpatrick J, Gatto L. A., Paskanik AM, Nieman GF. 2001. Invasive arterial blood pressure measurement in trauma and critical care: Effect of variable transducer level, catheter access and patient position. Chest, 120(4):1322-1326.
Schiller H.J., McCann II U.G., Carney D.E., Gatto L. A., Steinberg J.M., and Nieman G.F. 2001. "Altered alveolar mechanics in the acutely injured lung." Crit. Care Med., 29(5):1049-1055.
Year 1999
Carney D.E., Bredenberg C.E., Schiller H.J., Picone A.L., McCann II U.G., Gatto L. A., Bailey G., Fillinger M., and Nieman G.F. 1999. "The mechanism of lung volume change during mechanical ventilation." Am. J. Resp. Crit. Care Med., 160:1697-1702
Carney D.E., Lutz C.J., Picone A.L., Gatto L. A., Ramamurthy N.S., Golub L.M., Simon S.R., Searles B., Paskanik A., Snyder K., Finck C., Schiller H.J. and Nieman G.F. 1999. "Matrix metalloproteinase inhibitor prevents acute lung injury after cardiopulmonary bypass." Circulation, 100:400-406.
Carney D.E., Lutz C.J., Picone A.L., Gatto L. A., Schiller H.J., Finck C.M., Searles B., Paskanik A.M., Snyder K.P., Edwards C., and Nieman G.F. 1999. "Soluble tumor necrosis factor receptor prevents post-pump syndrome." J. Surg. Res., 83:113-121
Lutz C.J., Carney D.E., Picone A.L., Schiller H.J., Gatto L. A., Snyder K.P., Paskanik A.M., and Nieman G.F. 1999. "Videomicroscopy provides accurate in vivo assessment of pulmonary microvascular reactivity in rabbits." Shock, 11(5):367-371
McCann II U.G., Gatto L. A., Searles B., Carney D.E., Lutz C.J., Picone A.L., Schiller H.J. and Nieman G.F. 1999. "Matrix metalloproteinase inhibitor: Differential effects on pulmonary neutrophil and monocyte sequestration following cardiopulmonary bypass." J Extracorporeal Tech., 31(2):67-75.
McCann II U.G., Schiller H.J., Carney D.E., Gagne G.M., Thomas D., Hellwig B., Gatto L. A. and Nieman G.F. 1999. "Alveolar recruitment as a mechanism of normal lung volume change: Evidence from a novel nuclear imaging technique." Surg. Forum, 50:155-157.
Nieman G.F., Searles B., Carney D.E., McCann II U.G., Schiller H.J., Lutz C.J., Finck C.M., Gatto L. A., Hodell M. and Picone A.L. 1999. "Systemic inflammation induced by cardiopulmonary bypass: A review of pathogenesis and treatment." J. Extracorporeal Tech., 31(4):202-210.
Picone A.L., Lutz C.J., Finck C., Carney D.E., Gatto L. A., Paskanik A., Searles B., Snyder K., Nieman G. 1999. "Multiple sequential insults cause post-pump syndrome. Ann. Thorac. Surg., 67(4):978-985
Year 1998
Finck C.M., Hodell M.G., Marx W.H., Paskanik A.M., McGraw D.J., Lutz C.J., Gatto L. A., Picone A.L. and Nieman G.F. (1998). "Endotoxin-stimulated alveolar macrophage recruitment of neutrophils and modulation with exogenous surfactant." Crit. Care Med., 26(8): 1414-1418.
Lutz C., Carney D., Finck C., Picone A., Gatto L. A., Paskanik A., Langenback E. and Nieman G. (1998). "Aerosolized surfactant improves pulmonary function in endotoxin induced lung injury." Am. J. Resp. Crit. Care Med., 158:840-845
Lutz C.J., Picone A., Gatto L. A., Paskanik A., Landas S. and Nieman G.F. 1998. "Exogenous surfactant and positive end-expiratory pressure in the treatment of endotoxin-induced lung injury." Crit. Care Med., 26(8):1379-1389.
Year 1997
Lutz C., Picone A., Finck C., Searles B., Paskanik A., Hodell M., Lopez C., and Gatto L. A. 1997. "Antiprotease treatment prevents postperfusion acute respiratory distress." Surg. Forum, 48:309-311.
Year 1996
Nieman G. F., Gatto L. A., Paskanik A. M., Yang B., Fluck R., and Picone A. 1996. "Surfactant replacement in the treatment of sepsis induced adult respiratory distress syndrome (ARDS) in pigs." Crit. Care Med., 24(6):1025-1033.
Picone A., Gatto L. A., Nieman G. F., Paskanik A. M., and Lutz C. 1996. "Pulmonary surfactant function following endotoxin: Effects of exogenous surfactant treatment." Shock, 5(4):304-310.
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